| Secretariat of State |
| Secretariat of State |   Cardinal Pietro Parolin (70) |
| Section for General Affairs |   Archbishop Edgar Peña Parra (65) |
| Central Statistics Office of the Church | Vacant |
| Financial Security Committee | Vacant |
| Pontifical Commission for the Activities of Public Juridical Persons of the Church in the Healthcare Sector | Cardinal Pietro Parolin (70) |
| Section for Relations with States and International Organisations |  Archbishop Paul Richard Gallagher (71) |
| Council of the Section for Relations with States and International Organisations | Cardinal Pietro Parolin (70) |
| Section for Diplomatic Personnel of the Holy See | Archbishop Luciano Russo (62) |
| Dicasteries |
| Dicastery for Evangelisation |   Pope Leo XIV (70) |
| Section for Fundamental Questions regarding Evangelisation in the World | Archbishop Salvatore Fisichella (Rino) (74) |
| International Council for Catechesis | Archbishop Salvatore Fisichella (Rino) (74) |
| Section for the First Evangelisation and New Particular Churches |  Cardinal Luis Antonio Gokim Tagle (68) |
| Dicastery for the Doctrine of the Faith |  Cardinal Victor Manuel Fernández (63) |
| Doctrinal Section | |
| International Theological Commission | Cardinal Victor Manuel Fernández (63) |
| Pontifical Biblical Commission | Cardinal Victor Manuel Fernández (63) |
| Disciplinary Section | |
| Pontifical Commission for the Protection of Minors |   Archbishop Thibault Verny (60) |
| College for the review of appeals by clergy accused of delicta reservata |  Archbishop Charles Jude Scicluna (66) |
| Dicastery for the Service of Charity |   Cardinal Konrad Krajewski (62) |
| Dicastery for the Eastern Churches | Cardinal Claudio Gugerotti (70) |
| Dicastery for Divine Worship and the Discipline of the Sacraments | Cardinal Arthur Roche (75) |
| Committee for International Eucharistic Congresses |  Fr. Corrado Maggioni, S.M.M. (69) |
| Dicastery for the Causes of Saints | Cardinal Marcello Semeraro (77) |
| Commission of the New Martyrs – Witnesses of the Faith | Archbishop Fabio Fabene (66) |
| Dicastery for Bishops | Archbishop Filippo Iannone, O. Carm. (67) |
| Pontifical Commission for Latin America | Archbishop Filippo Iannone, O. Carm. (67) |
| Dicastery for the Clergy |  Cardinal Lazzaro You Heung-sik (유흥식 라자로 / 俞興植) (74) |
| Pontifical Work for Ecclesiastical Vocations | Cardinal Lazzaro You Heung-sik (유흥식 라자로 / 俞興植) (74) |
| Dicastery for Institutes of Consecrated Life and for Societies of Apostolic Life | Sr. Simona Brambilla, I.S.M.C. (60) |
| Dicastery for the Laity, Family and Life | Cardinal Kevin Joseph Farrell (78) |
| Pontifical Committee for World Children’s Day |  Fr. Enzo Fortunato, O.F.M. Conv. (59) |
| Dicastery for Promoting Christian Unity |  Cardinal Kurt Koch (75) |
| Commission for Religious Relations with the Jews | Cardinal Kurt Koch (75) |
| Dicastery for Interreligious Dialogue |  Cardinal George Jacob Koovakad (52) |
| Commission for Religious Relations with Muslims | Vacant |
| Dicastery for Culture and Education |  Cardinal José Tolentino Calaça de Mendonça (59) |
| Section for Culture | |
| Section for Education | |
| Dicastery for Promoting Integral Human Development |  Cardinal Michael Czerny, S.J. (79) |
| Vatican COVID-19 Commission | Cardinal Michael Czerny, S.J. (79) |
| Dicastery for Legislative Texts | Vacant |
| Dicastery for Communication | Dr. Paolo Ruffini (69) |
| L’Osservatore Romano | Prof. Andrea Monda (59) |
| Press Office of the Holy See | Dr. Matteo Bruni (49) |
| Institutions of Justice |
| Apostolic Penitentiary | Cardinal Angelo De Donatis (71) |
| Supreme Tribunal of the Apostolic Signatura | Cardinal Dominique François Joseph Mamberti (73) |
| Tribunal of the Roman Rota |  Archbishop Alejandro Arellano Cedillo, C.O.R.C. (63) |
| Pontifical Commission for the Verification and Application of Mitis Iudex in the Churches of Italy | Archbishop Alejandro Arellano Cedillo, C.O.R.C. (63) |
| Institutions of Finance |
| Council for the Economy |  Cardinal Reinhard Marx (72) |
| Secretariat for the Economy | Dr. Maximino Caballero Ledo (65) |
| Human Resources Department of the Holy See | Vacant |
| Administration of the Patrimony of the Apostolic See | Archbishop Giordano Piccinotti, S.D.B. (50) |
| Office of the Auditor General | Dr. Alessandro Cassinis Righini (59) |
| Commission for Confidential Matters | Cardinal Kevin Joseph Farrell (78) |
| Committee for Investments | Cardinal Kevin Joseph Farrell (78) |
| Offices |
| Prefecture of the Papal Household | Vacant |
| Office for the Liturgical Celebrations of the Supreme Pontiff | Archbishop Diego Giovanni Ravelli (60) |
| Pontifical Musical Chorus of the Sistine Chapel | Archbishop Diego Giovanni Ravelli (60) |
| Apostolic Camera | Cardinal Kevin Joseph Farrell (78) |
| Institutions Associated with the Holy See |
| Labour Office of the Apostolic See | Msgr. Marco Sprizzi (58) |
| Vatican Apostolic Archive | Archbishop Giovanni Cesare Pagazzi (60) |
| Vatican Apostolic Library | Archbishop Giovanni Cesare Pagazzi (60) |
| Fabric of Saint Peter | Cardinal Mauro Gambetti, O.F.M. Conv. (60) |
| Pontifical Commission for Sacred Archaeology | Msgr. Pasquale Iacobone (66) |
| AVEPRO | Fr. Armand Puig i Tàrrech (72) |
| Supervisory and Financial Information Authority | Dr. Carmelo Barbagallo (69) |
| Domus Vaticanæ |  Bishop Andrea Ripa (53) |
| Interdicastery Commissions |
| Interdicastery Commission on Particular Churches | Cardinal Pietro Parolin (70) |
| Interdicastery Commission for the Church in Eastern Europe | Cardinal Pietro Parolin (70) |
| Interdicastery Commission for Consecrated Religious | Cardinal Luis Antonio Gokim Tagle (68) |
| Interdicastery Commission for Candidates to Sacred Order | Cardinal Lazzaro You Heung-sik (유흥식 라자로 / 俞興植) (74) |
| Other Commissions and Committees |
| Commission for Advocates | Cardinal Dominique François Joseph Mamberti (73) |
| Pontifical Committee for Historical Sciences | Fr. Marek Andrzej Inglot, S.J. (64) |
| Pontifical Swiss Guard | Colonel Christoph Graf (64) |
| Disciplinary Commission of the Roman Curia | Prof. Vincenzo Buonomo (64) |
| Commission of Cardinals overseeing the Institute for Works of Religion |  Cardinal Christoph Schönborn, O.P. (80) |
