| Date of Death | Deceased Persons (41) |
| 2021.01.07 | Prefect Apostolic of Guapi (Colombia) (1994.05.05 – 2001.01.23) |
| 2021.01.09 | Personal Doctor of the Pope of Prefecture of the Papal Household (2015.08.08 – 2021.01.09) |
| 2021.01.13 | Priest of Tanga (Tanzania) (? – 2021.01.13) Chaplain of His Holiness (2019.11.11 – 2021.01.13) |
| 2021.01.25 | Prelate of Honour of His Holiness (1998.05.21 – 2021.01.25) |
| 2021.02 | Priest of Milano (Italy) (1957.06 – 2021.02) Protonotary Apostolic Supernumerary (1986.07.12 – 2021.02) |
| 2021.02.10 | Priest of Montréal (Canada) (? – 2021.02.10) Prelate of Honour of His Holiness (1969.09.17 – 2021.02.10) |
| 2021.02.20 | Priest of Gdańsk (Poland) (? – 2021.02.20) Chaplain of His Holiness (2005.12.05 – 2021.02.20) |
| 2021.03.08 | Secretary of Pontifical Committee for Historical Sciences (2002.11.16 – 2013.05.16) |
| 2021.03.12 | Priest of Köln (Germany) (? – 2021.03.12) Chaplain of His Holiness (1987.07.29 – 2021.03.12) |
| 2021.04.06 | Priest of Basel (Switzerland) (1954.10.10 – 2021.04.06) |
| 2021.04.23 | Priest of Płock (Poland) (? – 2021.04.23) Prelate of Honour of His Holiness (1987.03.07 – 2021.04.23) |
| 2021.05.02 | General Secretary of Namibian Catholic Bishop’s Conference (2021.03.16 – 2021.05.02) |
| 2021.05.12 | Priest of Saint Andrews and Edinburgh (Scotland) (? – 2021.05.12) Prelate of Honour of His Holiness (1994.12.15 – 2021.05.12) |
| 2021.05.14 | Priest of Altamura–Gravina–Acquaviva delle Fonti (Italy) (? – 2021.05.14) Chaplain of His Holiness (2010.06.19 – 2021.05.14) |
| 2021.05.17 | Priest of Malolos (Philippines) (? – 2021.05.17) Prelate of Honour of His Holiness (1983.05.19 – 2021.05.17) |
| 2021.05.26 | Priest of Portland in Oregon (USA) (1967.05 – 2021.05.26) Prelate of Honour of His Holiness (2007.08.13 – 2021.05.26) |
| 2021.06.05 | Priest of Alba Iulia (Romania) (? – 2021.06.05) Chaplain of His Holiness (1993.02.12 – 2021.06.05) |
| 2021.06.22 | Promoter of Justice of Tribunal of the Roman Rota (2005.01.10 – 2008.02.28) Undersecretary of Congregation for Institutes of Consecrated Life and for Societies of Apostolic Life (2008.02.28 – 2018.10.22) Referendary of Supreme Tribunal of the Apostolic Signatura (2018.10.22 – 2019.09.25) Promoter of Justice of Supreme Tribunal of the Apostolic Signatura (2019.09.25 – 2021.06.22) |
| 2021.06.25 | Priest of Roma (Italy) (? – 2021.06.25) Chaplain of His Holiness (1983.11.25 – 2005.09.19) Vice-Director of Press Office of the Holy See (1990 – 1994) Prelate of Honour of His Holiness (2005.09.19 – 2021.06.25) |
| 2021.06.25 | General Secretary of Zambia Conference of Catholic Bishops (2021.06.04 – 2021.06.25 not possessed) |
| 2021.07.11 | President of Vatican Philatelic and Numismatic Office (1989 – 2011.02.01) |
| 2021.07.19 | Rector Magnificus of Salesian Pontifical University (2009 – 2015.07.15) |
| 2021.07.28 | Priest of Taipei 臺北 (Taiwan) (? – 2021.07.28) Prelate of Honour of His Holiness (1993.02.27 – 2021.07.28) |
| 2021.07.28 | Founder of The Work of the Church (1959) President of The Work of the Church (1959 – 2021.07.28) |
| 2021.08.14 | Priest of Legnica (Poland) (? – 2021.08.14) Prelate of Honour of His Holiness (2004.04.04 – 2021.08.14) |
| 2021.08.16 | Priest of Ecatepec (Mexico) (? – 2021.08.16) Prelate of Honour of His Holiness (2002.10.03 – 2021.08.16) |
| 2021.08.21 | Priest of Espinal (Colombia) (? – 2021.08.21) Prelate of Honour of His Holiness (1989.10.02 – 2021.08.21) |
| 2021.08.22 | Priest of Santiago de Compostela (Spain) (? – 2021.08.22) Chaplain of His Holiness (2014.01.31 – 2021.08.22) |
| 2021.09.17 | Priest of Ischia (Italy) (? – 2021.09.17) Chaplain of His Holiness (1969.09.09 – 2021.09.17) |
| 2021.09.19 | Apostolic Administrator of Monrovia (Liberia) (2021.06.07 – 2021.09.19) |
| 2021.09.20 | Priest of Pavia (Italy) (? – 2021.09.20) Chaplain of His Holiness (2006.08.07 – 2021.09.20) |
| 2021.11.12 | Grand Master of Sovereign Military Hospitaller Order of Saint John of Jerusalem of Rhodes and of Malta (Knights of Malta) (2008.03.11 – 2017.01.28) |
| 2021.11.14 | Prior General of Order of Saint Paul the First Hermit (Pauline Fathers) (1963.07.23 – 1975.06.03) |
| 2021.11.18 | Priest of Pittsburgh (USA) (? – 2021.11.18) Prelate of Honour of His Holiness (1999.01.04 – 2021.11.18) |
| 2021.11.18 | Priest of Treviso (Italy) (? – 2021.11.18) Chaplain of His Holiness (2004.06.11 – 2021.11.18) |
| 2021.12.01 | Priest of Newark (USA) (? – 2021.12.01) Chaplain of His Holiness (2005.03.31 – 2021.12.01) |
| 2021.12.04 | Priest of Jbeil of the Maronites (Lebanon) (? – 2021.12.04) Prelate of Honour of His Holiness (1996.11.30 – 2021.12.04) Adjunct Promoter of Justice of Supreme Tribunal of the Apostolic Signatura (2000.04.06 – 2004.11.15) Prelate Auditor of Tribunal of the Roman Rota (2004.11.15 – 2021.12.04) |
| 2021.12.07 | Apostolic Commissioner for Franciscan Friars of the Immaculate (2015.07.01 – 2021.11.19) |
| 2021.12.28 | Priest of Fall River (USA) (? – 2021.12.28) Prelate of Honour of His Holiness (1987.07.18 – 2021.12.28) |
| 2021.12.30 | Priest of Skopje–Prizren (North Macedonia) (? – 2000.05.24) Chaplain of His Holiness (1986.10.15 – 2021.12.30) Priest of Prizren–Prishtina (Kosovo) (2000.05.24 – 2021.12.30) |
| 2021.12.31 | Priest of Alexandria (USA) (? – 2021.12.31) Chaplain of His Holiness (1973.12.14 – 2021.12.31) |
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