Date | Country | Change |
| 1502.01.24 |  Italy | Diocese of Città Ducale was established (from Diocese of Rieti) |
| 1503.11.26 | Italy | Diocese of Iglesias was established (from the suppressed Diocese of Sulci and became suffragan of Cagliari) |
| 1503.11.26 | Italy | Diocese of Sulci was suppressed (to establish Diocese of Iglesias) |
| 1503.12.08 | Italy | Diocese of Alghero was established (from Metropolitan Archdiocese of Sassari, from the suppressed Diocese of Bisarcio, Diocese of Castro and Diocese of Ottana and became suffragan of Sassari) |
| 1503.12.08 | Italy | Diocese of Bisarcio was suppressed (to establish Diocese of Alghero) |
| 1503.12.08 | Italy | Diocese of Castro was suppressed (to establish Diocese of Alghero) |
| 1503.12.08 | Italy | Diocese of Dolia was suppressed (to Metropolitan Archdiocese of Cagliari) |
| 1503.12.08 | Italy | Diocese of Ottana was suppressed (to establish Diocese of Alghero) |
| 1503.12.08 | Italy | Diocese of Ploaghe was suppressed (to Metropolitan Archdiocese of Sassari) |
| 1503.12.08 | Italy | Diocese of Santa Giusta was suppressed (to Metropolitan Archdiocese of Oristano) |
| 1503.12.08 | Italy | Diocese of Sorres was suppressed (to Metropolitan Archdiocese of Sassari) |
| 1504.11.15 |  Dominican Republic | Diocese of Bayuna was established (from Metropolitan Archdiocese of Sevilla and became suffragan of Hyaguata) |
| 1504.11.15 | Dominican Republic | Metropolitan Archdiocese of Hyaguata was established (from Metropolitan Archdiocese of Sevilla and with suffragan sees Bayuna and Magua) |
| 1504.11.15 | Dominican Republic | Diocese of Magua was established (from Metropolitan Archdiocese of Sevilla and became suffragan of Hyaguata) |
| 1505.11.08 | Italy | Diocese of Città Ducale was suppressed (to Diocese of Rieti) |
| 1506 |  Greece | Diocese of Modone was suppressed |
| 1507 | Italy | Apostolic Administration of Loreto was established (from Diocese of Recanati) |
| 1508.10.17 | Italy | Diocese of Città Ducale was restored (from Diocese of Rieti) |
| 1510.05.13 |  Spain | Diocese of Orihuela was restored (from Diocese of Cartagena and became suffragan of Valencia) |
| 1511.08.08 | Dominican Republic | Diocese of Bayuna was suppressed (to establish Diocese of Concepción de la Vega) |
| 1511.08.08 | Dominican Republic | Diocese of Concepción de la Vega was established (from the suppressed Metropolitan Archdiocese of Hyaguata, Diocese of Bayuna and Diocese of Magua and became suffragan of Sevilla) |
| 1511.08.08 | Dominican Republic | Metropolitan Archdiocese of Hyaguata was suppressed (to establish Diocese of Concepción de la Vega and Diocese of Santo Domingo) |
| 1511.08.08 | Dominican Republic | Diocese of Magua was suppressed (to establish Diocese of Concepción de la Vega and Diocese of Santo Domingo) |
| 1511.08.08 | Dominican Republic | Diocese of Santo Domingo was established (from the suppressed Metropolitan Archdiocese of Hyaguata and Diocese of Magua and became suffragan of Sevilla) |
| 1511.08.08 |  Puerto Rico | Diocese of Puerto Rico was established (from Metropolitan Archdiocese of Sevilla and became suffragan of Sevilla) |
| 1511.10.29 | Italy | Diocese of Saluzzo was established (from Diocese of Alba, Diocese of Asti and Diocese of Torino and without ecclesiastical province) |
| 1512 | Spain | Diocese of Ceuta lost territory to Metropolitan Archdiocese of Braga |
| 1512.02.01 | Italy | Diocese of Modena lost territory to Archpresbyterate nullius of Santa Maria Assunta di Carpi |
| 1512.02.01 | Italy | Abbacy nullius of Nonantola lost territory to Archpresbyterate nullius of Santa Maria Assunta di Carpi |
| 1513 | Italy | Territorial Abbacy of Santissima Trinità di Cava de’ Tirreni was established (from Diocese of Cava) |
| 1513.08.28 |  Panama | Diocese of Santa María la Antigua del Darién was established (from Diocese of Santo Domingo and became suffragan of Sevilla) |
| 1514.06.12 |  Portugal | Diocese of Funchal was established (from Diocese of Marruecos and became suffragan of Lisboa) |
| 1515 |  Jamaica | Abbacy nullius of Jamaica was established |
| 1515.05.01 | Italy | Diocese of Reggio Emilia lost territory to Archpresbyterate nullius of Santa Maria Assunta di Carpi |
| 1515.05.21 | Italy | Diocese of Torino was promoted as Metropolitan Archdiocese of Torino (with suffragan sees Asti, Ivrea and Mondovì) |
| 1515.06 |  France | Diocese of Bourg-en-Bresse was established (from Metropolitan Archdiocese of Lyon and became suffragan of Lyon) |
| 1515.06.27 | Italy | Diocese of Chieti lost territory to Diocese of Lanciano |
| 1515.06.27 | Italy | Archpresbyterate nullius of Lanciano was promoted as Diocese of Lanciano (gained territory from Diocese of Chieti and without ecclesiastical province) |
| 1515.09.22 | Italy | Diocese of Arezzo lost territory to Abbacy nullius of Sansepolcro |
| 1515.09.22 | Italy | Diocese of Città di Castello lost territory to Abbacy nullius of Sansepolcro |
| 1516 | France | Diocese of Ajaccio lost territory to Metropolitan Archdiocese of Genova |
| 1517.02.11 |  Cuba | Diocese of Baracoa was established (from Diocese of Santo Domingo and became suffragan of Sevilla) |
| 1518.01.27 |  Mexico | Diocese of Carolense was established (from Metropolitan Archdiocese of Sevilla and became suffragan of Sevilla) |
| 1518.04.01 | Spain | Diocese of Orihuela was suppressed (to Diocese of Cartagena) |
| 1519 | Dominican Republic | Diocese of Santo Domingo lost territory to Diocese of Puerto Rico |
| 1519.04.15 | Italy | Territorial Prelature of Pescia was established (from Diocese of Lucca and Diocese of Pistoia and without ecclesiastical province) |
| 1520 | Greece | Diocese of Corone was suppressed |
| 1520 |  Romania | Diocese of Argeș was suppressed |
| 1520.09.17 | Italy | Abbacy nullius of Sansepolcro was promoted as Diocese of Sansepolcro (became suffragan of Firenze) |
| 1520.12.07 | Panama | Diocese of Santa María la Antigua del Darién was renamed as Diocese of Panamá |
| 1521 |  Serbia | Diocese of Beograd lost territory to Diocese of Csanád |
| 1522 | Greece | Diocese of Naxos was promoted as Metropolitan Archdiocese of Naxos (with suffragan sees Santorini and Syros) |
| 1522.04.28 | Cuba | Diocese of Baracoa was suppressed (to establish Diocese of Santiago) |
| 1522.04.28 | Cuba | Diocese of Santiago was established (from the suppressed Diocese of Baracoa and became suffragan of Sevilla) |
| 1522.07.22 |  Finland | Diocese of Åbo was suppressed |
| 1523 | Greece | Metropolitan Archdiocese of Rhodes was suppressed |
| 1523 | Italy | Diocese of Salpi was restored (from Metropolitan Archdiocese of Trani) |
| 1524 |  Poland | Diocese of Pomezania was suppressed (to Diocese of Chełmno) |
| 1524.05.11 | Spain | Titular Patriarchal See of Indias Occidentales was established |
| 1525 | Romania | Diocese of Baia was suppressed |
| 1525.06.19 | Italy | Diocese of Campagna was established (from Metropolitan Archdiocese of Salerno and Diocese of Satriano and became suffragan of Salerno) |
| 1525.10.13 | Mexico | Diocese of Carolense was suppressed (to establish Diocese of Tlaxcala) |
| 1525.10.13 | Mexico | Diocese of Tlaxcala was established (from the suppressed Diocese of Carolense and became suffragan of Sevilla) |
| 1525.12.10 |  Russia | Diocese of Sambia was suppressed |
| 1526.06.01 | Italy | Diocese of Chieti was promoted as Metropolitan Archdiocese of Chieti (with suffragan sees Atri, Lanciano and Penne) |
| 1527 |  Honduras | Diocese of Honduras was established (from Diocese of Santo Domingo and became suffragan of Sevilla) |
| 1527 |  Syria | Diocese of Damascus (Maronite Rite) was established (without ecclesiastical province) |
| 1527.01.13 |  Sweden | Diocese of Skara was suppressed |
| 1530 |  Wales,  England | Diocese of Llandaff was suppressed |
| 1530.03.14 | Italy | Diocese of Vigevano was established (from Diocese of Novara and Diocese of Pavia and became suffragan of Milano) |
| 1530.09.02 | Mexico | Diocese of México was established (from Diocese of Tlaxcala and became suffragan of Sevilla) |
| 1530.10.04 | Sweden | Diocese of Växjö was suppressed |
| 1531.03.06 | Italy | Diocese of Giffoni was established (from Metropolitan Archdiocese of Salerno and Diocese of Acerno) |
| 1531.06.21 |  Venezuela | Diocese of Coro was established (from Diocese of Santo Domingo and became suffragan of Sevilla) |
| 1531.09.06 | Honduras | Diocese of Honduras was renamed as Diocese of Trujillo |
| 1532.06.28 | Italy | Diocese of Giffoni was suppressed (to Metropolitan Archdiocese of Salerno and Diocese of Acerno) |
| 1533.01.31 |  Cabo Verde | Diocese of Santiago de Cabo Verde was established (from Diocese of Funchal and became suffragan of Funchal) |
| 1533.01.31 |  India | Diocese of Goa was established (from Diocese of Funchal and became suffragan of Funchal) |
| 1533.01.31 | Portugal | Diocese of Funchal was promoted as Metropolitan Archdiocese of Funchal (with suffragan sees Goa and Santiago de Cabo Verde and lost territory to establish Diocese of Goa and Diocese of Santiago de Cabo Verde) |
| 1534 |  Croatia | Diocese of Otočac was suppressed (to Diocese of Senj) |
| 1534 | Italy | Diocese of Sarno lost territory to Diocese of Nola |
| 1534 | Sweden | Diocese of Västerås was suppressed |
| 1534.01.04 | France | Diocese of Bourg-en-Bresse was suppressed (to Metropolitan Archdiocese of Lyon) |
| 1534.01.10 |  Colombia | Diocese of Santa Marta was established (from Diocese of Santo Domingo and became suffragan of Sevilla) |
| 1534.04.24 | Colombia | Diocese of Cartagena was established (from Diocese of Panamá and became suffragan of Sevilla) |
| 1534.11.03 |  Nicaragua | Diocese of León was established (from Diocese of Panamá and became suffragan of Sevilla) |
| 1534.11.03 | Portugal | Diocese of Angra was established (from Metropolitan Archdiocese of Funchal and became suffragan of Funchal) |
| 1534.11.03 |  São Tomé and Príncipe | Diocese of Tomé was established (from Metropolitan Archdiocese of Funchal and became suffragan of Funchal) |
| 1534.12.18 |  Guatemala | Diocese of Guatemala was established (from Diocese of Santo Domingo and became suffragan of Sevilla) |
| 1535 | England | Diocese of Hereford was suppressed |
| 1535 | Italy | Diocese of Pavia lost territory to Diocese of Vigevano |
| 1535.06.21 | Mexico | Diocese of Antequera was established (from Diocese of Tlaxcala and became suffragan of Sevilla) |
| 1536 |  Denmark | Diocese of Odense was suppressed |
| 1536 | Denmark | Diocese of Roskilde was suppressed |
| 1536 | Denmark | Diocese of Århus was suppressed |
| 1536 |  Germany | Diocese of Lübeck was suppressed |
| 1536 |  Montenegro | Diocese of Risano was suppressed (to Diocese of Kotor) |
| 1536.03.27 | France | Diocese of Maguelonne was renamed as Diocese of Montpellier |
| 1536.08.11 | Mexico | Diocese of Michoacán was established (from Diocese of México and became suffragan of Sevilla) |
| 1536.09.05 |  Peru | Diocese of Cusco was established (from Metropolitan Archdiocese of Sevilla and became suffragan of Sevilla) |
| 1537 |  Greenland | Diocese of Gardar was suppressed |
| 1537 | Italy | Diocese of Tusculum–Frascati was renamed as Diocese of Frascati |
| 1537 |  Norway | Diocese of Bjørgvin was suppressed |
| 1537 | Norway,  Bouvet Island | Diocese of Oslo was suppressed |
| 1537 | Norway | Diocese of Stavanger was suppressed |
| 1537 | Sweden | Diocese of Strängnäs was suppressed |
| 1538 |  Faroe Islands | Diocese of Fær Øer was suppressed |
| 1538 | France | Abbacy nullius of Saint-Oyand de Joux was renamed as Abbacy nullius of Saint-Claude |
| 1538 | Norway | Metropolitan Archdiocese of Nidaros was suppressed |
| 1538.08.01 | Sweden | Diocese of Linköping was suppressed |
| 1539 | England | Diocese of Coventry and Lichfield was suppressed |
| 1539.02.09 | Denmark | Diocese of Ribe was suppressed |
| 1539.03.19 | Mexico | Diocese of Chiapas was established (from Diocese of Antequera and became suffragan of Sevilla) |
| 1540.09.24 | Portugal | Diocese of Évora was promoted as Metropolitan Archdiocese of Évora (with suffragan sees Ceuta, Marruecos and Silves) |
| 1541 | Croatia | Diocese of Ston was restored (from Diocese of Korcula) |
| 1541 | England | Diocese of Chester was restored (became suffragan of York) |
| 1541.05.14 | Peru | Diocese of Lima was established (from Diocese of Cusco and became suffragan of Sevilla) |
| 1541.09.03 | England | Diocese of Gloucester was established (from former Diocese of Hereford and Diocese of Worcester) |
| 1541.09.05 | England | Diocese of Peterborough was established |
| 1542 | England | Diocese of Bristol was established (from Diocese of Bath and Wells) |
| 1542 |  Iceland | Diocese of Skálholt was suppressed |
| 1542 | Norway | Diocese of Hamar was suppressed |
| 1542 | Romania | Diocese of Milcovia was suppressed (to Metropolitan Archdiocese of Esztergom) |
| 1542.09.01 | England | Diocese of Oxford was established |
| 1543.06.06 | Mexico | Diocese of Puebla–Tlaxcala was established (from the suppressed Diocese of Tlaxcala and became suffragan of Sevilla) |
| 1543.06.06 | Mexico | Diocese of Tlaxcala was suppressed (to establish Diocese of Puebla–Tlaxcala) |
| 1544 | Serbia | Diocese of Smederevo was established |
| 1545 | Poland | Diocese of Kamień was suppressed |
| 1545.01.08 |  Ecuador | Diocese of Quito was established (from Diocese of Lima and became suffragan of Sevilla) |
| 1545.05.22 | Portugal | Diocese of Leiria was established (from Diocese of Coimbra and became suffragan of Braga) |
| 1545.05.22 | Portugal | Diocese of Miranda was established (from Metropolitan Archdiocese of Braga and became suffragan of Braga) |
| 1545.08.08 | Italy | Diocese of Anglona was renamed as Diocese of Anglona–Tursi |
| 1546.02.12 | Dominican Republic | Diocese of Santo Domingo was promoted as Metropolitan Archdiocese of Santo Domingo (with suffragan sees Cartagena, Concepción de la Vega, Coro, Puerto Rico, Santa Marta, Santiago, Trujillo and Jamaica) |
| 1546.02.12 | Mexico | Diocese of México was promoted as Metropolitan Archdiocese of México (with suffragan sees Antequera, Chiapas, Guatemala, Michoacán and Puebla–Tlaxcala) |
| 1546.02.12 | Peru | Diocese of Lima was promoted as Metropolitan Archdiocese of Lima (with suffragan sees Cusco, Panamá and Quito) |
| 1546.08.22 | Colombia | Diocese of Popayán was established (from Diocese of Panamá and became suffragan of Lima) |
| 1547 | Denmark | Diocese of Viborg was suppressed |
| 1547.04.22 | Italy | Diocese of Salpi was suppressed (to Metropolitan Archdiocese of Trani) |
| 1547.07.01 |  Paraguay | Diocese of Paraguay was established (from Diocese of Cusco and became suffragan of Lima) |
| 1548 | Germany | Diocese of Havelberg was suppressed |
| 1548.07.13 | Mexico | Diocese of Nueva Galicia was established (from Diocese of Michoacán and became suffragan of México) |
| 1549.08.21 | Portugal | Diocese of Portalegre was established (from Diocese of Guarda and became suffragan of Lisboa) |
| 1550 |  Albania | Diocese of Croia was suppressed (to Diocese of Lezhë) |
| 1550 | Albania | Diocese of Dagno was suppressed |
| 1550 | Iceland | Diocese of Hólar was suppressed |
| 1550 | Montenegro | Titular Episcopal See of Risinium was restored |
| 1550 | Romania | Diocese of Moldovita was suppressed |
| 1550 |  Scotland | Diocese of Caithness was suppressed |
| 1550 | Scotland | Diocese of Ross was suppressed |
| 1550 |  Turkiye | Titular Episcopal See of Martiria was restored |
| 1551 | Denmark | Diocese of Børglum was suppressed |
| 1551 | Germany | Metropolitan Archdiocese of Magdeburg was suppressed |
| 1551.02.25 |  Brazil | Diocese of São Salvador da Bahia de Todos os Santos was established (from Metropolitan Archdiocese of Funchal and became suffragan of Funchal) |
| 1551.07.03 | Portugal | Metropolitan Archdiocese of Funchal was demoted as Diocese of Funchal (became suffragan of Lisboa) |
| 1551.10.05 | Greece | Diocese of Ario was suppressed (to Diocese of Retimo–Ario) |
| 1551.10.05 | Greece | Diocese of Retimo was renamed as Diocese of Retimo–Ario (gained territory from the suppressed Diocese of Ario) |
| 1552.06.27 |  Bolivia | Diocese of La Plata was established (from Diocese of Cusco and became suffragan of Lima) |
| 1553 |  Iran | Archdiocese of Urmyā (Chaldean Rite) was established |
| 1553 | Turkiye | Diocese of Diarbekir (Chaldean Rite) was established (without ecclesiastical province) |
| 1553 | Turkiye | Diocese of Gazireh (Chaldean Rite) was established |
| 1553 | Turkiye | Diocese of Mardin (Chaldean Rite) was established |
| 1553 | Turkiye | Diocese of Seert (Chaldean Rite) was established |
| 1553.01 | Sweden | Metropolitan Archdiocese of Lund was suppressed |
| 1553.04.20 |  Iraq | Metropolitan Archdiocese of Babylon (Chaldean Rite) was promoted as Patriarchal See of Babylon |
| 1553.04.20 | Iraq | Metropolitan Archdiocese of Baghdad (Chaldean Rite) was established |
| 1554.10.05 | Germany | Diocese of Ratzeburg was suppressed |
| 1555 |  Ethiopia | Patriarchal See of Ethiopia was established |
| 1555 | Germany | Diocese of Lebus was suppressed |
| 1555 | Germany | Diocese of Schwerin was suppressed |
| 1556 | Poland | Titular Episcopal See of Kamień was restored |
| 1557 | England | Diocese of Salisbury was suppressed |
| 1557 |  Estonia | Diocese of Reval was suppressed |
| 1558 | England | Diocese of Bristol was suppressed |
| 1558 | England | Metropolitan Archdiocese of Canterbury was suppressed |
| 1558 | England | Diocese of Durham was suppressed |
| 1558 | England | Diocese of Ely was suppressed |
| 1558 | England | Diocese of Gloucester was suppressed |
| 1558 | England | Diocese of Norwich was suppressed |
| 1558 | England | Diocese of Oxford was suppressed |
| 1558 | England | Diocese of Rochester was suppressed |
| 1558 | Estonia | Diocese of Dorpat was suppressed |
| 1558 | Scotland | Diocese of Whithorn was suppressed |
| 1558 | Wales | Diocese of Bangor was suppressed |
| 1558 | Wales | Diocese of Saint David’s was suppressed |
| 1558.02.04 | India | Diocese of Cochin was established (from Diocese of Goa and became suffragan of Goa) |
| 1558.02.04 | India | Diocese of Goa was promoted as Metropolitan Archdiocese of Goa (with suffragan sees Cochin and Malacca and lost territory to establish Diocese of Cochin and Diocese of Malacca) |
| 1558.02.04 |  Malaysia | Diocese of Malacca was established (from Diocese of Goa and became suffragan of Goa) |
| 1558.09.14 | Scotland | Diocese of Kirkwall was suppressed |
| 1559 | England | Diocese of Chester was suppressed |
| 1559 | England | Diocese of Chichester was suppressed |
| 1559 | England | Diocese of Peterborough was suppressed |
| 1559 | Germany | Apostolic Prefecture of Lausitz was established (from Diocese of Meißen) |
| 1559.05.12 |  Belgium | Diocese of Antwerpen was established (from Diocese of Cambrai and Diocese of Liège and became suffragan of Mechelen) |
| 1559.05.12 | Belgium | Diocese of Brugge was established (from Diocese of Tournai and became suffragan of Mechelen) |
| 1559.05.12 | Belgium | Diocese of Gent was established (from Diocese of Cambrai, Diocese of Tournai and Diocese of Utrecht and became suffragan of Mechelen) |
| 1559.05.12 | Belgium | Diocese of Ieper was established (from Diocese of Tournai, gained territory from Diocese of Thérouanne and became suffragan of Mechelen) |
| 1559.05.12 | Belgium | Metropolitan Archdiocese of Mechelen was established (from Diocese of Cambrai and Diocese of Liège and with suffragan sees Antwerpen, Brugge, Gent, Ieper and ’s-Hertogenbosch) |
| 1559.05.12 | Belgium | Diocese of Namur was established (from Diocese of Cambrai and Diocese of Liège and became suffragan of Cambrai) |
| 1559.05.12 | France | Diocese of Cambrai was promoted as Metropolitan Archdiocese of Cambrai (with suffragan sees Arras, Namur, Saint-Omer and Tournai and lost territory to establish Metropolitan Archdiocese of Mechelen, Diocese of Antwerpen, Diocese of Gent and Diocese of Namur) |
| 1559.05.12 | France | Diocese of Saint-Omer was established (from Diocese of Thérouanne and Diocese of Tournai and became suffragan of Cambrai) |
| 1559.05.12 | France | Diocese of Thérouanne lost territory to Diocese of Ieper |
| 1559.05.12 |  Netherlands | Diocese of Deventer was established (from Diocese of Utrecht and became suffragan of Utrecht) |
| 1559.05.12 | Netherlands | Diocese of Groningen was established (from Diocese of Münster and Diocese of Utrecht and became suffragan of Utrecht) |
| 1559.05.12 | Netherlands | Diocese of Haarlem was established (from Diocese of Utrecht and became suffragan of Utrecht) |
| 1559.05.12 | Netherlands | Diocese of Leeuwarden was established (from Diocese of Utrecht and became suffragan of Utrecht) |
| 1559.05.12 | Netherlands | Diocese of Middelburg was established (from Diocese of Utrecht and became suffragan of Utrecht) |
| 1559.05.12 | Netherlands | Diocese of Roermond was established (from Metropolitan Archdiocese of Köln and Diocese of Liège and became suffragan of Köln) |
| 1559.05.12 | Netherlands | Diocese of Utrecht was promoted as Metropolitan Archdiocese of Utrecht (with suffragan sees Deventer, Groningen, Haarlem, Leeuwarden and Middelburg and lost territory to establish Diocese of Deventer, Diocese of Gent, Diocese of Groningen, Diocese of Haarlem, Diocese of Leeuwarden and Diocese of Middelburg) |
| 1559.05.12 | Netherlands | Diocese of ’s-Hertogenbosch was established (from Diocese of Liège and became suffragan of Mechelen) |
| 1560 | England | Diocese of Carlisle was suppressed |
| 1560 | England | Diocese of Exeter was suppressed |
| 1560 | England | Diocese of Winchester was suppressed |
| 1560 | Estonia | Diocese of Saare-Lääne was suppressed |
| 1560 | Greece | Titular Episcopal See of Nisyros was restored |
| 1560 | Scotland | Diocese of Sodor was suppressed |
| 1560.05.10 | Mexico | Diocese of Nueva Galicia was renamed as Diocese of Guadalajara |
| 1560.06 | Germany | Diocese of Brandenburg was suppressed |
| 1560.08.07 | Scotland | Diocese of Argyll was suppressed |
| 1560.08.07 | Scotland | Diocese of Dunkeld was suppressed |
| 1561 | Honduras | Diocese of Comayagua was established (from the suppressed Diocese of Trujillo and became suffragan of Santo Domingo) |
| 1561 | Honduras | Diocese of Trujillo was suppressed (to establish Diocese of Comayagua) |
| 1561 |  Latvia | Metropolitan Archdiocese of Riga was suppressed |
| 1561.01.09 | Italy | Diocese of Lanciano was promoted as Metropolitan Archdiocese of Lanciano |
| 1561.06.21 | Guatemala | Diocese of Vera Paz was established (from Diocese of Guatemala and became suffragan of México) |
| 1561.06.27 |  Chile | Diocese of Santiago was established (from Metropolitan Archdiocese of Lima and Diocese of La Plata and became suffragan of Lima) |
| 1561.11.10 | Italy | Diocese of Arezzo lost territory to Diocese of Montepulciano |
| 1561.11.10 | Italy | Diocese of Chiusi lost territory to Diocese of Montepulciano |
| 1561.11.10 | Italy | Collegiate nullius of Montepulciano was promoted as Diocese of Montepulciano (gained territory from Diocese of Arezzo and Diocese of Chiusi and without ecclesiastical province) |
| 1561.11.19 | Mexico | Diocese of Yucatán was restored (from Diocese of Puebla–Tlaxcala and became suffragan of México) |
| 1562.09.11 | Colombia | Diocese of Santa Marta was suppressed (to establish Diocese of Santafé en Nueva Granada) |
| 1562.09.11 | Colombia | Diocese of Santafé en Nueva Granada was established (from the suppressed Diocese of Santa Marta and became suffragan of Santo Domingo) |
| 1563 | France | Diocese of Mariana was renamed as Diocese of Mariana et Acci |
| 1563.01.30 | France | Diocese of Accia was suppressed (to Diocese of Mariana et Acci) |
| 1563.03.17 | Italy | Diocese of Gallese was restored (from Diocese of Civita Castellana) |
| 1563.05.22 | Chile | Diocese of La Imperial was established (from Diocese of Santiago and became suffragan of Lima) |
| 1563.06.04 | Italy | Diocese of Urbino was promoted as Metropolitan Archdiocese of Urbino (with suffragan sees Cagli, Gubbio, Montefeltro, Pesaro and Senigallia) |
| 1564 | Germany | Diocese of Naumburg was suppressed |
| 1564.03.22 | Colombia | Diocese of Santafé en Nueva Granada was promoted as Metropolitan Archdiocese of Santafé en Nueva Granada (with suffragan see Popayán) |
| 1564.07.14 | Spain | Diocese of Orihuela was restored (from Diocese of Cartagena and became suffragan of Valencia) |
| 1565 |  Cyprus | Territorial Abbacy of Holy Saviour of Nicosia (Ethiopic Rite) was established |
| 1565 | England | Diocese of Worcester was suppressed |
| 1565 | Germany | Diocese of Merseburg was suppressed |
| 1565 | Montenegro | Diocese of Ulcinj was suppressed (to Diocese of Budua) |
| 1565.02.23 | India | Archdiocese of Angamaly (Chaldean Rite) was established |
| 1565.04 |  Philippines | Abbacy nullius of Cebu was established |
| 1566 | France | Diocese of Bayonne lost territory to Diocese of Pamplona |
| 1566 | Germany | Metropolitan Archdiocese of Hamburg–Bremen was suppressed |
| 1567 | Italy | Diocese of Lesina was suppressed (to Diocese of Larino) |
| 1567.03.03 | France | Diocese of Boulogne was established (from the suppressed Diocese of Thérouanne and became suffragan of Reims) |
| 1567.03.03 | France | Diocese of Thérouanne was suppressed (to establish Diocese of Boulogne) |
| 1568 |  Isle of Man | Diocese of Man was suppressed |
| 1569 | England | Diocese of Bath and Wells was suppressed |
| 1569 | England | Diocese of London was suppressed |
| 1569 | Scotland | Diocese of Dunblane was suppressed |
| 1569.09.16 | Italy | Diocese of Gallese was suppressed (to Diocese of Civita Castellana) |
| 1570 | Cyprus | Archdiocese of Nicosia was suppressed (to Titular Patriarchal See of Jerusalem) |
| 1570 | Cyprus | Diocese of Paphos was suppressed (to Titular Patriarchal See of Jerusalem) |
| 1570.05.10 |  Argentina | Diocese of Tucumán was established (from Diocese of Santiago and became suffragan of Lima) |
| 1570.06.09 |  Morocco | Diocese of Marruecos was suppressed (to Diocese of Ceuta y Tánger) |
| 1570.06.09 | Portugal | Diocese of Elvas was established (from Metropolitan Archdiocese of Évora, Diocese of Badajoz and Diocese of Ceuta) |
| 1570.06.09 | Spain | Diocese of Ceuta was renamed as Diocese of Ceuta y Tánger (gained territory from the suppressed Diocese of Marruecos and lost territory to establish Diocese of Elvas) |
| 1570.07.01 | Cyprus | Territorial Abbacy of Holy Saviour of Nicosia (Ethiopic Rite) was suppressed |
| 1570.10.20 | Italy | Diocese of Ortona was restored (from Metropolitan Archdiocese of Lanciano and became suffragan of Chieti) |
| 1571 | Cyprus | Diocese of Famagosta was suppressed (to Titular Patriarchal See of Jerusalem) |
| 1571 | Cyprus | Diocese of Limassol was suppressed (to Titular Patriarchal See of Jerusalem) |
| 1571 | Montenegro | Diocese of Svač was suppressed (to Diocese of Shkodrë) |
| 1571 | Scotland | Metropolitan Archdiocese of Saint Andrews was suppressed |
| 1571.06.18 | Spain | Diocese of Huesca–Jaca was renamed as Diocese of Huesca (lost territory to establish Diocese of Jaca) |
| 1571.06.18 | Spain | Diocese of Jaca was restored (from Diocese of Huesca–Jaca and became suffragan of Zaragoza) |
| 1571.07.16 | Greece | Diocese of Hierapetra was renamed as Diocese of Hierapetra–Sitia (gained territory from the suppressed Diocese of Sitia) |
| 1571.07.16 | Greece | Diocese of Sitia was suppressed (to Diocese of Hierapetra–Sitia) |
| 1571.08.01 | Italy | Abbacy nullius of Farfa lost territory to Diocese of Ascoli Piceno |
| 1571.08.01 | Italy | Diocese of Ripatransone was established (from Diocese of Ascoli Piceno, Diocese of Fermo, Diocese of Teramo and Abbacy nullius of Farfa) |
| 1571.11.27 | Italy | Diocese of San Leone was suppressed (to Metropolitan Archdiocese of Santa Severina) |
| 1573.02.09 | Spain | Diocese of Barbastro was restored (from Diocese of Huesca and Diocese of Lérida and became suffragan of Zaragoza) |
| 1574.10.22 | Spain | Diocese of Burgos was promoted as Metropolitan Archdiocese of Burgos (with suffragan sees Calahorra y La Calzada and Pamplona) |
| 1575 | Turkiye | Archdiocese of Smirne was suppressed |
| 1575.07.19 | Brazil | Territorial Prelature of São Sebastião do Rio de Janeiro was established (from Diocese of São Salvador da Bahia de Todos os Santos and became suffragan of Lisboa) |
| 1576.01.23 |  Macau | Diocese of Macau 澳門 was established (from Diocese of Malacca and became suffragan of Goa) |
| 1577 | Scotland | Diocese of Aberdeen was suppressed |
| 1577.03.30 | Portugal | Diocese of Silves was renamed as Diocese of Faro |
| 1577.04.14 | Colombia | Diocese of Santa Marta was restored (from Metropolitan Archdiocese of Santafé en Nueva Granada and became suffragan of Santafé en Nueva Granada) |
| 1577.04.15 | Peru | Diocese of Arequipa was established (from Metropolitan Archdiocese of Lima and became suffragan of Lima) |
| 1577.04.15 | Peru | Diocese of Trujillo was established (from Metropolitan Archdiocese of Lima and became suffragan of Lima) |
| 1577.07.21 | Spain | Diocese of Albarracin was restored (from Diocese of Segorbe–Albarracín) |
| 1577.07.21 | Spain | Diocese of Segorbe–Albarracín was renamed as Diocese of Segorbe (lost territory to establish Diocese of Albarracin) |
| 1577.07.31 | Spain | Diocese of Teruel was established (from Metropolitan Archdiocese of Zaragoza and became suffragan of Zaragoza) |
| 1579 | England | Metropolitan Archdiocese of York was suppressed |
| 1579.02.06 | Philippines | Diocese of Manila was established (from Metropolitan Archdiocese of México and Abbacy nullius of Cebu and became suffragan of México) |
| 1580.02.15 | Netherlands | Diocese of Leeuwarden was suppressed |
| 1580.02.15 | Netherlands | Metropolitan Archdiocese of Utrecht was suppressed |
| 1580.02.21 | Italy | Diocese of Civitate was suppressed (to establish Diocese of San Severo) |
| 1580.02.21 | Italy | Diocese of Dragonara was suppressed (to establish Diocese of San Severo) |
| 1580.02.21 | Italy | Diocese of San Severo was established (from the suppressed Diocese of Civitate and Diocese of Dragonara and became suffragan of Benevento) |
| 1580.04.11 | Italy | Diocese of Crema was established (from Diocese of Cremona, Diocese of Lodi and Diocese of Piacenza and became suffragan of Milano) |
| 1580.10.17 |  Ireland | Diocese of Annaghdown was suppressed (to Metropolitan Archdiocese of Tuam) |
| 1581.10 | Germany | Diocese of Meißen was suppressed (to Apostolic Prefecture of Lausitz) |
| 1582.12.10 | Italy | Diocese of Bologna was promoted as Metropolitan Archdiocese of Bologna (with suffragan sees Cervia, Crema, Imola, Modena, Parma, Piacenza and Reggio Emilia) |
| 1584 | England | Diocese of Lincoln was suppressed |
| 1585 | Portugal | Metropolitan Archdiocese of Lisboa lost territory to Diocese of Leiria |
| 1585 | Wales | Diocese of Saint Asaph was suppressed |
| 1585.05.01 | Latvia, Estonia | Diocese of Wenden was established (without ecclesiastical province) |
| 1585.11.05 | Italy | Archpresbyterate nullius of Guastalla was promoted as Abbacy nullius of San Pietro Apostolo di Guastalla |
| 1586 | Italy | Diocese of Osimo lost territory to Diocese of Recanati |
| 1586.03.17 | Italy | Apostolic Administration of Loreto was promoted as Diocese of Loreto (gained territory from Diocese of Macerata, gained territory from the suppressed Diocese of Recanati and without ecclesiastical province) |
| 1586.03.17 | Italy | Diocese of Macerata lost territory to Diocese of Loreto |
| 1586.03.17 | Italy | Diocese of Recanati was suppressed (to Diocese of Loreto) |
| 1586.07.17 | Italy | Diocese of Capaccio was renamed as Diocese of Capaccio–Diano |
| 1586.11.24 | Italy | Diocese of Montalto was established (from Diocese of Ascoli Piceno, Diocese of Fermo, Diocese of Ripatransone and Diocese of Teramo and without ecclesiastical province) |
| 1586.11.26 | Italy | Diocese of San Severino was restored (from Diocese of Camerino) |
| 1586.11.26 | Italy | Diocese of Spoleto lost territory to Diocese of Camerino |
| 1586.12.10 | Italy | Diocese of Tolentino was restored (from Diocese of Camerino) |
| 1588 | Italy | Diocese of Camerino lost territory to Diocese of Macerata |
| 1588 | Sweden | Metropolitan Archdiocese of Uppsala was suppressed |
| 1588.02.19 |  Japan | Diocese of Funai 府内 was established (from Diocese of Macau 澳門 and became suffragan of Goa) |
| 1589.05.24 | Italy | Diocese of Fermo was promoted as Metropolitan Archdiocese of Fermo (with suffragan sees Macerata, Montalto, Ripatransone, San Severino and Tolentino) |
| 1590 | Romania | Diocese of Bacău was established (from former Diocese of Argeș) |
| 1591 | Netherlands | Diocese of Deventer was suppressed |
| 1591.05.08 | Italy | Metropolitan Archdiocese of Brindisi–Oria was renamed as Metropolitan Archdiocese of Brindisi (lost territory to establish Diocese of Oria) |
| 1591.05.08 | Italy | Diocese of Oria was established (from Metropolitan Archdiocese of Brindisi–Oria and became suffragan of Taranto) |
| 1592 | Netherlands | Apostolic Vicariate of Batavia was restored |
| 1592 | Netherlands | Diocese of Haarlem was suppressed |
| 1592.02.09 | Italy | Diocese of Recanati was restored (from Diocese of Loreto) |
| 1592.04.15 | Italy | Diocese of Fossano was established (from Metropolitan Archdiocese of Torino and Diocese of Asti and became suffragan of Torino) |
| 1592.06.05 | Italy | Collegiate nullius of Colle di Val d’Elsa was promoted as Diocese of Colle di Val d’Elsa (gained territory from Metropolitan Archdiocese of Firenze, Metropolitan Archdiocese of Siena, Diocese of Fiesole and Diocese of Volterra and became suffragan of Firenze) |
| 1592.06.05 | Italy | Diocese of Fiesole lost territory to Diocese of Colle di Val d’Elsa |
| 1592.06.05 | Italy | Metropolitan Archdiocese of Firenze lost territory to Diocese of Colle di Val d’Elsa |
| 1592.06.05 | Italy | Metropolitan Archdiocese of Siena lost territory to Diocese of Colle di Val d’Elsa |
| 1592.06.05 | Italy | Diocese of Volterra lost territory to Diocese of Colle di Val d’Elsa |
| 1593.07.19 | Spain | Diocese of Solsona was established (from Diocese of Urgell and Diocese of Vic and became suffragan of Tarragona) |
| 1594.05.02 |  Ukraine | Diocese of Lutsk–Ostroh (Ukrainian Rite) was established |
| 1595.08.14 | Philippines | Abbacy nullius of Cebu was promoted as Diocese of Cebu (gained territory from Diocese of Manila and became suffragan of Manila) |
| 1595.08.14 | Philippines | Diocese of Manila was promoted as Metropolitan Archdiocese of Manila (with suffragan sees Cebu, Nueva Caceres and Nueva Segovia, lost territory to Diocese of Cebu and lost territory to establish Diocese of Nueva Caceres and Diocese of Nueva Segovia) |
| 1595.08.14 | Philippines | Diocese of Nueva Caceres was established (from Diocese of Manila and became suffragan of Manila) |
| 1595.08.14 | Philippines | Diocese of Nueva Segovia was established (from Diocese of Manila and became suffragan of Manila) |
| 1595.09.25 | Spain | Diocese of Valladolid was established (from Diocese of Palencia and became suffragan of Burgos) |
| 1596 |  Belarus | Diocese of Pinsk–Turaŭ (Ukrainian Rite) was established |
| 1596 | Belarus | Archdiocese of Polatsk–Vitebsk (Ukrainian Rite) was established |
| 1596 | Poland | Diocese of Chełm–Bełz (Ukrainian Rite) was established |
| 1596 | Ukraine | Metropolitan Archdiocese of Kyiv–Halyč (Ukrainian Rite) was established |
| 1596 | Ukraine | Diocese of Luck and Włodzimierz was renamed as Diocese of Luck |
| 1596 | Ukraine, Belarus | Diocese of Volodymyr–Brėst (Ukrainian Rite) was established |
| 1596.05.20 |  Angola | Diocese of São Salvador da Congo was established (from Diocese of Tomé and became suffragan of Lisboa) |
| 1599.12.20 | India | Archdiocese of Angamaly (Chaldean Rite) was suppressed (to establish Diocese of Angamalé) |
| 1599.12.20 | India | Diocese of Angamalé was established (from the suppressed Archdiocese of Angamaly and became suffragan of Goa) |
| 1600 | Albania | Archdiocese of Durrës (Albanese Rite) was established |
| 1600 | Albania | Diocese of Sarda was suppressed (to Diocese of Sapë) |
| 1600 |  Algeria | Titular Episcopal See of Milevum was restored |
| 1600 | Cyprus | Titular Episcopal See of Ceraunia was suppressed |
| 1600 | Cyprus | Titular Metropolitan See of Salamis postea Constantia was restored |
| 1600 | Greece | Diocese of Argos was suppressed |
| 1600 | Greece | Diocese of Kisamos was suppressed |
| 1600 | Greece | Titular Episcopal See of Negroponte was suppressed |
| 1600 | Greece | Titular Episcopal See of Nisyros was suppressed |
| 1600 | Greece | Titular Episcopal See of Rheon was suppressed |
| 1600 | Greece | Diocese of Ceo was renamed as Diocese of Thermia |
| 1600 |  Lebanon | Titular Archiepiscopal See of Heliopolis was restored |
| 1600 | Lebanon | Diocese of Saidnaya (Greek-Melkite Rite) was established |
| 1600 | Lebanon | Diocese of Saïdā (Maronite Rite) was established |
| 1600 | Lebanon | Diocese of Tyr (Maronite Rite) was established (without ecclesiastical province) |
| 1600 |  Palestine | Titular Episcopal See of Maioren was suppressed |
| 1600 | Palestine | Titular Metropolitan See of Scythopolis was restored |
| 1600 | Spain | Military Vicariate of Spain was established |
| 1600 | Turkiye | Metropolitan Archdiocese of Amasea was suppressed |
| 1600 | Turkiye | Titular Metropolitan See of Ancyra was restored |
| 1600 | Turkiye | Titular Episcopal See of Comanæ was restored |
| 1600 | Turkiye | Metropolitan Archdiocese of Gangra was suppressed |
| 1600 | Turkiye | Titular Metropolitan See of Iconium was restored |
| 1600 | Turkiye | Titular Episcopal See of Lampsacus was restored |
| 1600 | Turkiye | Titular Metropolitan See of Neocæsarea was restored |
| 1600 | Turkiye | Titular Episcopal See of Verissa was suppressed |
| 1600 | | Titular Episcopal See of Andravida was established |
| 1600 | | Titular Episcopal See of Dschebail was suppressed |
| 1600 | | Titular Episcopal See of Siriensis was established |
| 1600.05.12 | Italy | Diocese of Campli was established (from Diocese of Montalto and Diocese of Teramo) |
| 1600.09.25 | Italy | Diocese of Città della Pieve was restored (from Diocese of Chiusi) |
