| Date | Country | Change |
| 1999 | Titular Episcopal See of Sisak was restored | |
| 1999.01.02 | Diocese of Gulu was promoted as Metropolitan Archdiocese of Gulu (with suffragan sees Arua, Lira and Nebbi) | |
| 1999.01.02 | Diocese of Mbarara was promoted as Metropolitan Archdiocese of Mbarara (with suffragan sees Fort Portal, Hoima, Kabale and Kasese) | |
| 1999.01.02 | Diocese of Tororo was promoted as Metropolitan Archdiocese of Tororo (with suffragan sees Jinja, Kotido, Moroto and Soroti) | |
| 1999.02.09 | Diocese of Mamfe was established (from Diocese of Buéa and became suffragan of Bamenda) | |
| 1999.02.09 | Diocese of Gwalior was established (from Diocese of Jhansi and became suffragan of Bhopal) | |
| 1999.02.09 | Diocese of Masvingo was established (from Diocese of Gweru and became suffragan of Bulawayo) | |
| 1999.03.03 | Diocese of Caraguatatuba was established (from Diocese of Santos and became suffragan of São Paulo) | |
| 1999.03.16 | Diocese of Yendi was established (from Metropolitan Archdiocese of Tamale and became suffragan of Tamale) | |
| 1999.03.16 | Diocese of Patna was promoted as Metropolitan Archdiocese of Patna (with suffragan sees Bettiah, Bhagalpur, Muzaffarpur and Purnea) | |
| 1999.03.16 | Diocese of Arusha was promoted as Metropolitan Archdiocese of Arusha (with suffragan sees Mbulu, Moshi and Same) | |
| 1999.04.24 | Diocese of Belthangady (Syro-Malabar Rite) was established (from Metropolitan Archdiocese of Tellicherry and became suffragan of Tellicherry) | |
| 1999.05.18 | Apostolic Administration of Eastern Siberia was established (from Apostolic Administration of Novosibirsk) | |
| 1999.05.18 | Apostolic Administration of Novosibirsk was renamed as Apostolic Administration of Western Siberia (lost territory to establish Apostolic Administration of Eastern Siberia) | |
| 1999.06.03 | Diocese of Ambositra was established (from Metropolitan Archdiocese of Fianarantsoa and became suffragan of Fianarantsoa) | |
| 1999.06.05 | Diocese of Batroun (Maronite Rite) was restored (from Diocese of Joubbé–Sarba and without ecclesiastical province) | |
| 1999.06.05 | Diocese of Joubbé–Sarba (Maronite Rite) was renamed as Diocese of Jebbeh–Sarba–Jounieh (gained territory from the suppressed Diocese of Jounieh and lost territory to establish Diocese of Batroun) | |
| 1999.06.05 | Diocese of Jounieh (Maronite Rite) was suppressed (to Diocese of Jebbeh–Sarba–Jounieh) | |
| 1999.06.22 | Diocese of Nassau was promoted as Metropolitan Archdiocese of Nassau (with suffragan sees Hamilton and Turks and Caicos Islands) | |
| 1999.06.22 | Apostolic Vicariate of Kano was promoted as Diocese of Kano (became suffragan of Kaduna) | |
| 1999.06.23 | Diocese of Adilabad (Syro-Malabar Rite) was established (from Diocese of Chanda and became suffragan of Hyderabad) | |
| 1999.07.07 | Apostolic Administration of Almaty was established (from Apostolic Administration of Kazakhstan) | |
| 1999.07.07 | Apostolic Administration of Astana was established (from Apostolic Administration of Kazakhstan) | |
| 1999.07.07 | Apostolic Administration of Atyrau was established (from Apostolic Administration of Kazakhstan) | |
| 1999.07.07 | Apostolic Administration of Kazakhstan was promoted as Diocese of Karaganda (lost territory to establish Apostolic Administration of Almaty, Apostolic Administration of Astana and Apostolic Administration of Atyrau) | |
| 1999.10.13 | Diocese of Vitebsk was established (from Metropolitan Archdiocese of Minsk–Mohilev and became suffragan of Minsk–Mohilev) | |
| 1999.10.29 | Apostolic Vicariate of Ariari was promoted as Diocese of Granada (became suffragan of Bogotá) | |
| 1999.10.29 | Apostolic Vicariate of Sibundoy was promoted as Diocese of Mocoa–Sibundoy (became suffragan of Popayán) | |
| 1999.10.29 | Apostolic Vicariate of San José del Guaviare was promoted as Diocese of San José del Guaviare (became suffragan of Bogotá) | |
| 1999.10.29 | Apostolic Vicariate of Trinidad was established (from Apostolic Vicariate of Casanare) | |
| 1999.10.29 | Apostolic Vicariate of Tumaco was promoted as Diocese of Tumaco (became suffragan of Popayán) | |
| 1999.10.29 | Apostolic Vicariate of Casanare was promoted as Diocese of Yopal (lost territory to establish Apostolic Vicariate of Trinidad and became suffragan of Tunja) | |
| 1999.11.10 | Diocese of Osório was established (from Metropolitan Archdiocese of Porto Alegre and Diocese of Caxias do Sul and became suffragan of Porto Alegre) | |
| 1999.11.20 | Metropolitan Archdiocese of Paraíba lost territory to Diocese of Guarabira | |
| 1999.11.23 | Apostolic Administration of European Russia was renamed as Apostolic Administration of Northern European Russia (lost territory to establish Apostolic Administration of Southern European Russia) | |
| 1999.11.23 | Apostolic Administration of Southern European Russia was established (from Apostolic Administration of European Russia) | |
| 1999.12.22 | Diocese of N’Dali was established (from Metropolitan Archdiocese of Parakou and became suffragan of Parakou) | |
| 1999.12.22 | Apostolic Prefecture of Vichada was promoted as Apostolic Vicariate of Puerto Carreño (lost territory to Apostolic Vicariate of Inírida and lost territory to establish Apostolic Vicariate of Puerto Gaitán) | |
| 1999.12.22 | Apostolic Vicariate of Puerto Gaitán was established (from Apostolic Prefecture of Vichada) | |
| 1999.12.22 | Diocese of Wiawso was established (from Diocese of Sekondi–Takoradi and became suffragan of Cape Coast) | |
| 1999.12.22 | Diocese of Kolda was established (from Diocese of Ziguinchor and became suffragan of Dakar) |
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