 | 1999 | 2000 | 2001 |  |
Date | Country | Change |
| 2000 |  Chile | Titular Episcopal See of La Imperial was restored |
| 2000 |  Croatia | Titular Episcopal See of Krbava was restored |
| 2000 | Croatia | Titular Episcopal See of Modruš was restored |
| 2000 |  Philippines | Military Ordinariate of Military Ordinariate of the Philippines lost territory to Metropolitan Archdiocese of Manila |
| 2000 |  Slovenia | Titular Episcopal See of Ptuj was restored |
| 2000.02.09 |  Brazil | Diocese of Catanduva was established (from Diocese of Jaboticabal, Diocese of Rio Preto and Diocese of São Carlos and became suffragan of Ribeirão Preto) |
| 2000.02.17 |  Colombia | Apostolic Prefecture of Tierradentro was promoted as Apostolic Vicariate of Tierradentro |
| 2000.03.11 |  Italy | Diocese of Pesaro was promoted as Metropolitan Archdiocese of Pesaro (with suffragan sees Urbino–Urbania–Sant’Angelo in Vado and Fano–Fossombrone–Cagli–Pergola) |
| 2000.03.11 | Italy | Metropolitan Archdiocese of Urbino–Urbania–Sant’Angelo in Vado was demoted as Archdiocese of Urbino–Urbania–Sant’Angelo in Vado (became suffragan of Pesaro) |
| 2000.03.15 |  Indonesia | Metropolitan Archdiocese of Ujung Pandang was renamed as Metropolitan Archdiocese of Makassar |
| 2000.04.04 |  Venezuela | Diocese of Carúpano was established (from Metropolitan Archdiocese of Cumaná and became suffragan of Cumaná) |
| 2000.04.14 |  Burkina Faso | Diocese of Nouna–Dédougou was renamed as Diocese of Dédougou (lost territory to establish Diocese of Nouna) |
| 2000.04.14 | Burkina Faso | Diocese of Nouna was restored (from Diocese of Nouna–Dédougou and became suffragan of Ouagadougou) |
| 2000.04.15 |  Mexico | Diocese of Córdoba was established (from Metropolitan Archdiocese of Jalapa and became suffragan of Jalapa) |
| 2000.04.15 | Mexico | Diocese of Orizaba was established (from Metropolitan Archdiocese of Jalapa and became suffragan of Jalapa) |
| 2000.04.19 | Brazil | Diocese of Blumenau was established (from Metropolitan Archdiocese of Florianópolis, Diocese of Joinville and Diocese of Rio do Sul and became suffragan of Florianópolis) |
| 2000.05.10 |  India | Diocese of Bongaigaon was established (from Metropolitan Archdiocese of Guwahati and became suffragan of Guwahati) |
| 2000.05.18 |  Paraguay | Diocese of San Lorenzo was established (from Metropolitan Archdiocese of Asunción and became suffragan of Asunción) |
| 2000.05.24 |  Kosovo | Apostolic Administration of Prizren was restored (from Diocese of Skopje–Prizren) |
| 2000.05.24 |  North Macedonia | Diocese of Skopje–Prizren was renamed as Diocese of Skopje (lost territory to establish Apostolic Administration of Prizren) |
| 2000.05.25 | Croatia,  Bosnia and Herzegovina | Diocese of Gospić–Senj was established (from Metropolitan Archdiocese of Rijeka–Senj and became suffragan of Rijeka) |
| 2000.05.25 | Croatia | Metropolitan Archdiocese of Rijeka–Senj was renamed as Metropolitan Archdiocese of Rijeka (lost territory to establish Diocese of Gospić–Senj and gained suffragan see Gospić–Senj) |
| 2000.06.02 |  Kenya | Diocese of Malindi was established (from Metropolitan Archdiocese of Mombasa and Diocese of Garissa and became suffragan of Mombasa) |
| 2000.06.03 | Mexico | Territorial Prelature of Nuevo Casas Grandes was promoted as Diocese of Nuevo Casas Grandes |
| 2000.07.03 |  USA | Diocese of Laredo was established (from Metropolitan Archdiocese of San Antonio and Diocese of Corpus Christi and became suffragan of San Antonio) |
| 2000.07.05 | Brazil | Diocese of Janaúba was established (from Diocese of Januária and Diocese of Montes Claros and became suffragan of Diamantina) |
| 2000.07.11 |  Guatemala | Diocese of Santa Cruz del Quiché was renamed as Diocese of Quiché |
| 2000.07.14 |  Cayman Islands | Mission sui juris of Cayman Islands was established (from Metropolitan Archdiocese of Kingston in Jamaica and became suffragan of Kingston in Jamaica) |
| 2000.07.21 |  Ukraine | Diocese of Bučač (Ukrainian Rite) was established (from Diocese of Ternopil) |
| 2000.07.21 | Ukraine | Diocese of Sokal (Ukrainian Rite) was established (from Major Archdiocese of Lviv–Halyč–Kamyanets and Diocese of Ternopil and from the suppressed Diocese of Zboriv) |
| 2000.07.21 | Ukraine | Diocese of Stryj (Ukrainian Rite) was established (from Major Archdiocese of Lviv–Halyč–Kamyanets) |
| 2000.07.21 | Ukraine | Diocese of Ternopil (Ukrainian Rite) was renamed as Diocese of Ternopil–Zboriv (gained territory from the suppressed Diocese of Zboriv and lost territory to establish Diocese of Bučač and Diocese of Sokal) |
| 2000.07.21 | Ukraine | Diocese of Zboriv (Ukrainian Rite) was suppressed (to Diocese of Ternopil–Zboriv and to establish Diocese of Sokal) |
| 2000.10.11 |  Azerbaijan | Mission sui juris of Baku was established (from Apostolic Administration of Caucasus) |
| 2000.10.23 | Colombia | Apostolic Prefecture of Leticia was promoted as Apostolic Vicariate of Leticia |
| 2000.10.23 |  Tanzania | Diocese of Mpanda was established (from Diocese of Sumbawanga and became suffragan of Tabora) |
| 2000.10.30 |  Congo-Brazzaville | Apostolic Prefecture of Likouala was established (from Diocese of Ouesso and became suffragan of Brazzaville) |
| 2000.10.30 |  Madagascar | Diocese of Fenoarivo Atsinanana was established (from Metropolitan Archdiocese of Antsiranana and became suffragan of Antsiranana) |
| 2000.11.16 |  Ethiopia | Apostolic Prefecture of Gambella was established (from Apostolic Prefecture of Jimma–Bonga) |
| 2000.11.25 |  Argentina | Diocese of Gregorio de Laferrere was established (from Diocese of San Justo and became suffragan of Buenos Aires) |
| 2000.11.25 |  Lithuania | Military Ordinariate of Lietuvos kariuomenės ordinariatas was established |
| 2000.12.02 | Italy | Diocese of Agrigento was promoted as Metropolitan Archdiocese of Agrigento (with suffragan sees Caltanissetta and Piazza Armerina) |
| 2000.12.02 | Italy | Archdiocese of Catania was promoted as Metropolitan Archdiocese of Catania (with suffragan sees Acireale and Caltagirone) |
| 2000.12.02 | Italy | Metropolitan Archdiocese of Monreale was demoted as Archdiocese of Monreale (became suffragan of Palermo) |
| 2000.12.05 | Burkina Faso | Diocese of Bobo-Dioulasso was promoted as Metropolitan Archdiocese of Bobo-Dioulasso (with suffragan sees Banfora, Dédougou, Diébougou and Nouna) |
| 2000.12.05 | Burkina Faso | Diocese of Koupéla was promoted as Metropolitan Archdiocese of Koupéla (with suffragan sees Fada N’Gourma and Kaya) |
| 2000.12.05 | Colombia | Apostolic Prefecture of San Andrés y Providencia was promoted as Apostolic Vicariate of San Andrés y Providencia |
| 2000.12.05 |  Nigeria | Diocese of Lafia was established (from Metropolitan Archdiocese of Jos and Diocese of Makurdi and became suffragan of Abuja) |
| 2000.12.05 | Nigeria | Diocese of Zaria was established (from Metropolitan Archdiocese of Kaduna and became suffragan of Kaduna) |
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