| Date | Country | Change |
| 2012.01.01 | Personal Ordinariate of The Chair of Saint Peter (Anglican Rite) was established | |
| 2012.01.14 | Diocese of Ifakara was established (from Diocese of Mahenge and became suffragan of Dar-es-Salaam) | |
| 2012.02.11 | Diocese of Tenkodogo was established (from Metropolitan Archdiocese of Koupéla and Diocese of Fada N’Gourma and became suffragan of Koupéla) | |
| 2012.02.11 | Apostolic Prefecture of Robe was established (from Apostolic Vicariate of Meki) | |
| 2012.02.24 | Diocese of Segheneity (Eritrean Rite) was established (from Diocese of Asmara and became suffragan of Addis Abeba) | |
| 2012.03.06 | Diocese of Faridabad (Syro-Malabar Rite) was established | |
| 2012.05.26 | Diocese of Bafang was established (from Diocese of Nkongsamba and became suffragan of Douala) | |
| 2012.06.15 | Personal Ordinariate of Our Lady of the Southern Cross (Anglican Rite) was established | |
| 2012.07.03 | Diocese of Batticaloa was established (from Diocese of Trincomalee–Batticaloa and became suffragan of Colombo) | |
| 2012.07.03 | Diocese of Trincomalee–Batticaloa was renamed as Diocese of Trincomalee (lost territory to establish Diocese of Batticaloa) | |
| 2012.07.16 | Diocese of Udupi was established (from Diocese of Mangalore and became suffragan of Bangalore) | |
| 2012.07.17 | Papal See of Roma lost territory to Diocese of Ostia | |
| 2012.07.21 | Diocese of Notre-Dame du Liban de Paris (Maronite Rite) was established (without ecclesiastical province) | |
| 2012.08.20 | Territorial Abbacy of Santissima Trinità di Cava de’ Tirreni lost territory to Archdiocese of Amalfi–Cava de’ Tirreni | |
| 2012.12.29 | Diocese of Gboko was established (from Diocese of Makurdi and became suffragan of Abuja) | |
| 2012.12.29 | Diocese of Katsina-Ala was established (from Diocese of Makurdi and became suffragan of Abuja) |
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