(11) | Paul V | Gregory XV | Urban VIII |  |
| Consistory of 1621.02.15 (at the time of creation) (1) | ||
| 1. |   Fr. Ludovico Ludovisi (25), Commendatory Abbot of Nonantola (Italy) | Cardinal-Priest |
| Consistory of 1621.04.19 (at the time of creation) (4) | ||
| 1. |  Archbishop Antonio Caetani (55), Metropolitan Archbishop of Capua (Italy) | Cardinal-Priest |
| 2. | Archbishop Francesco Sacrati (54), Titular Archbishop of Damascus and Datary of His Holiness of Apostolic Dataria | Cardinal-Priest |
| 3. |  Fr. Francesco Boncompagni (29) | Cardinal-Deacon |
| 4. | Mr. Ippolito Aldobrandini (25) | Cardinal-Deacon |
| Consistory of 1621.07.21 (at the time of creation) (2) | ||
| 1. | Archbishop Lucio Sanseverino (56), Metropolitan Archbishop of Salerno (Italy) | Cardinal-Priest |
| 2. | Fr. Marcantonio Gozzadini (47) | Cardinal-Priest |
| Consistory of 1622.09.05 (at the time of creation) (4) | ||
| 1. |  Archbishop Cosimo de Torres (38), Titular Archbishop of Adrianopolis | Cardinal-Priest |
| 2. |   Bishop Armand-Jean du Plessis de Richelieu (36), Bishop of Luçon (France) | Cardinal-Priest |
| 3. | Bishop Ottavio Ridolfi (40), Bishop of Ariano (Italy) | Cardinal-Priest |
| 4. |  Fr. Alfonso de la Cueva-Benavides y Mendoza-Carrillo (50) | Cardinal-Priest |
| Paul V | Gregory XV | Urban VIII | |
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