| Date | Country | Change |
| 1988 | Archdiocese of Amalfi–Cava de’ Tirreni lost territory to Metropolitan Archdiocese of Salerno–Campagna–Acerno | |
| 1988 | Diocese of Nardò–Gallipoli lost territory to Archdiocese of Otranto | |
| 1988 | Archdiocese of Otranto lost territory to Metropolitan Archdiocese of Lecce and Diocese of Ugento–Santa Maria di Leuca | |
| 1988.01.14 | Diocese of Lexington was established (from Metropolitan Archdiocese of Louisville and Diocese of Covington and became suffragan of Louisville) | |
| 1988.01.18 | Diocese of Khammam was established (from Diocese of Warangal and became suffragan of Hyderabad) | |
| 1988.01.23 | Diocese of Belley was renamed as Diocese of Belley–Ars | |
| 1988.02.23 | Diocese of Massa was renamed as Diocese of Massa Carrara–Pontremoli (gained territory from the suppressed Diocese of Pontremoli) | |
| 1988.02.23 | Diocese of Pontremoli was suppressed (to Diocese of Massa Carrara–Pontremoli) | |
| 1988.02.25 | Diocese of Jacmel was established (from Metropolitan Archdiocese of Port-au-Prince and became suffragan of Port-au-Prince) | |
| 1988.02.27 | Diocese of Nuestra Señora del Paraíso en México (Greek-Melkite Rite) was established (without ecclesiastical province) | |
| 1988.03.12 | Apostolic Administration of Izabal was promoted as Apostolic Vicariate of Izabal | |
| 1988.03.21 | Apostolic Vicariate of La Paz was promoted as Diocese of La Paz | |
| 1988.03.25 | Metropolitan Archdiocese of Ciudad Bolívar lost territory to Diocese of Ciudad Guayana | |
| 1988.04.07 | Diocese of Cap-Haïtien was promoted as Metropolitan Archdiocese of Cap-Haïtien (with suffragan sees Hinche, Les Gonaïves and Port-de-Paix) | |
| 1988.04.08 | Diocese of Wankie was renamed as Diocese of Hwange | |
| 1988.04.23 | Diocese of Luxembourg was promoted as Archdiocese of Luxembourg | |
| 1988.04.30 | Diocese of Kalyan (Syro-Malabar Rite) was established (gained territory from Diocese of Poona and became suffragan of Bombay) | |
| 1988.04.30 | Diocese of Poona lost territory to Diocese of Kalyan | |
| 1988.05.27 | Diocese of Knoxville was established (from Diocese of Nashville and became suffragan of Louisville) | |
| 1988.06.01 | Diocese of Strasbourg was promoted as Archdiocese of Strasbourg | |
| 1988.06.11 | Diocese of Corbeil was renamed as Diocese of Évry–Corbeil-Essonnes | |
| 1988.06.11 | Archdiocese of Antélias (Maronite Rite) was established (from Archdiocese of Cyprus and without ecclesiastical province) | |
| 1988.06.18 | Diocese of Apartadó was established (from Diocese of Antioquía, gained territory from Apostolic Vicariate of Quibdó and became suffragan of Santa Fe de Antioquia) | |
| 1988.06.18 | Diocese of Caldas was established (from Metropolitan Archdiocese of Medellín and became suffragan of Medellín) | |
| 1988.06.18 | Diocese of Girardota was established (from Metropolitan Archdiocese of Medellín, Diocese of Barrancabermeja and Diocese of Sonsón–Rionegro and became suffragan of Medellín) | |
| 1988.06.18 | Apostolic Vicariate of Quibdó lost territory to Diocese of Apartadó | |
| 1988.06.18 | Diocese of Antioquía was promoted as Metropolitan Archdiocese of Santa Fe de Antioquia (with suffragan sees Apartadó and Santa Rosa de Osos and lost territory to establish Diocese of Apartadó) | |
| 1988.07.06 | Territorial Prelature of Itaituba was established (from Diocese of Santarém and became suffragan of Belém do Pará) | |
| 1988.07.16 | Apostolic Vicariate of Riohacha was promoted as Diocese of Riohacha (became suffragan of Barranquilla) | |
| 1988.11.05 | Diocese of San Luis Potosí was promoted as Metropolitan Archdiocese of San Luis Potosí (with suffragan sees Celaya, Ciudad Valles, León and Querétaro) | |
| 1988.11.14 | Diocese of Shimoga was established (from Metropolitan Archdiocese of Bangalore and Diocese of Chikmagalur and became suffragan of Bangalore) | |
| 1988.11.14 | Diocese of Loikaw was established (from Diocese of Taunggyi and became suffragan of Rangoon) | |
| 1988.11.29 | Diocese of Naval was established (from Metropolitan Archdiocese of Palo and became suffragan of Palo) | |
| 1988.12.12 | Territorial Prelature of Chulucanas was promoted as Diocese of Chulucanas | |
| 1988.12.15 | Diocese of Colón was established (from Apostolic Vicariate of Darién and became suffragan of Panamá) | |
| 1988.12.15 | Territorial Abbacy of Pietersburg was promoted as Diocese of Pietersburg |
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