| Date | Country | Change |
| 1840 | Archdiocese of Durrës (Albanese Rite) was suppressed | |
| 1840 | Titular Episcopal See of Pinsk–Turaŭ (Ukrainian Rite) was suppressed | |
| 1840 | Diocese of Eastern District was established (from Apostolic Vicariate of Midland District) | |
| 1840 | Apostolic Vicariate of Lancashire District was established (from Apostolic Vicariate of Northern District) | |
| 1840 | Apostolic Vicariate of Wales District was established (from Apostolic Vicariate of Western District) | |
| 1840 | Diocese of Batroun–Jbeil (Maronite Rite) lost territory to Archdiocese of Tripoli | |
| 1840 | Apostolic Vicariate of Limburg was restored (from Metropolitan Archdiocese of Köln and Diocese of Liège) | |
| 1840 | Titular Episcopal See of Bethlehem was restored (from former Diocese of Bethléem à Clamecy) | |
| 1840 | Apostolic Prefecture of Jedda was established (from Apostolic Vicariate of Egypt and Arabia) | |
| 1840.04.27 | Diocese of California was established (from Diocese of Sonora and became suffragan of México) | |
| 1840.05.11 | Apostolic Vicariate of Yorkshire District was established (from Apostolic Vicariate of Northern District) | |
| 1840.05.21 | Diocese of Santiago was promoted as Metropolitan Archdiocese of Santiago (with suffragan see Concepción) | |
| 1840.06.02 | Apostolic Vicariate of Luxembourg was established (from Diocese of Liège and Diocese of Namur) | |
| 1840.07.01 | Diocese of La Serena was established (from Metropolitan Archdiocese of Santiago and became suffragan of Santiago) | |
| 1840.07.01 | Diocese of San Carlos de Ancud was established (from Diocese of Concepción and became suffragan of Santiago) | |
| 1840.07.03 | Apostolic Vicariate of Midland District was renamed as Apostolic Vicariate of Central District | |
| 1840.08.20 | Apostolic Vicariate of Liaotung 遼東 was renamed as Apostolic Vicariate of Liaotung and Manchuria 遼東滿州 (lost territory to establish Apostolic Vicariate of Mongolia 蒙古) | |
| 1840.08.20 | Apostolic Vicariate of Mongolia 蒙古 was established (from Apostolic Vicariate of Liaotung 遼東) | |
| 1840.08.28 | Apostolic Vicariate of Yunnan 雲南 was restored (from Apostolic Vicariate of Szechwan 四川) |
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