| Prefect: |  Cardinal Francesco Salesio Della Volpe (1911.01.26 – 1916.11.05) |
| Prefect: | Cardinal Francesco Segna (1908.01.13 – 1911.01.04) |
| Prefect: |  Cardinal Andreas Steinhuber, S.J. (1896.10.01 – 1907.10.15) |
| Prefect: | Cardinal Serafino Vannutelli (1893.12.09 – 1896.10.01) |
| Prefect: | Cardinal Camillo Mazzella, S.J. (1889.02.20 – 1893.06.22) |
| Prefect: | Cardinal Placido Maria Schiaffino, O.S.B. Oliv. (1888.04.06 – 1889.09.23) |
| Prefect: | Cardinal Tommaso Maria Martinelli, O.E.S.A. (1878.07.15 – 1883.03.15?) |
| Prefect: | Cardinal Antonio Saverio De Luca (1864.12.28 – 1878) |
| Prefect: | Cardinal Lodovico Altieri (1861.09.05 – 1867.08.11) |
| Prefect: | Cardinal Girolamo D’Andrea (1853.07.04 – 1861.07.31) |
| Prefect: | Cardinal Giacomo Luigi Brignole (1849 – 1853.06.23) |
| Prefect: | Cardinal Angelo Mai (1843.03.11 – 1848) |
| Prefect: | Cardinal Giacomo Giustiniani (1834.11.21 – 1837.07.01) |
| Prefect: | Cardinal Giuseppe Antonio Sala (1834.03.21 – 1839.06.23) |
| Prefect: | Cardinal Pietro Caprano (1829.04.04 – 1834.02.24) |
| Prefect: | Cardinal Francesco Saverio Castiglioni (later Pope Pius VIII) (1821.11.14 – 1829.03.31) |
| Prefect: | Cardinal Benedetto Naro (1818.11.29 – 1821.02.10) |
| Prefect: | Cardinal Michele Di Pietro (1818 – 1821.07.02?) |
| Prefect: | Cardinal Francesco Luigi Fontana, B. (1816.06.30 – 1818.09.24) |
| Prefect: | Cardinal Lorenzo Litta (1803.08.27 – 1809?) |
| Prefect: | Cardinal Michelangelo Luchi, O.S.B. Cas. (1802.08.18 – 1802.09.29) |
| Prefect: | Cardinal Stefano Borgia (1801 – 1802) |
| Prefect: |  Cardinal Hyacinthe Sigismond Gerdil, B. (1800.01? – 1802.08.12) |
| Prefect: | Cardinal Benedetto Veterani (1775? – 1776.08.12) |
| Prefect: | Cardinal Antonio Andrea Galli, C.R.L. (1765? – 1767.03.24) |
| Prefect: | Cardinal Leandro Porzia, O.S.B. Cas. (1740.01 – 1740.06.02) |
| Prefect: | Cardinal Angelo Maria Quirini, O.S.B. Cas. (1740 – 1755.01.06?) |
| Prefect: | Cardinal Gianantonio Davia (1737? – 1740.01.11) |
| Prefect: | Cardinal Tommaso Maria Ferrari, O.P. (1696? – ?) |
| Prefect: | Cardinal Girolamo Casanate (1693? – 1700.03.03) |
| Prefect: | Saint Cardinal Roberto Bellarmino (Robert Bellarmine), S.J. (1620? – 1621.09.17) |
| Prefect: | Cardinal Girolamo Bernerio, O.P. (1603 – 1611.08.05) |
| Prefect: |  Cardinal Philippe de Lenoncourt (1588 – 1592.12.13) |
| Prefect: | Cardinal Agostino Valier (1587.02.08 – 1597.03.14) |
| Prefect: | Cardinal Archangelo de’ Bianchi, O.P. (1575? – ?) |
| Secretary: | Bishop Hermann Joseph (Thomas) Esser, O.P. (1900.01.20 – 1926.03.13) |
| Secretary: | Fr. Gregorio Selleri, O.P. (later Cardinal) (1707 – 1726?) |
| Secretary: | Fr. Raimondo Capizucchi, O.P. (later Cardinal) (1650 – ?) |
(x 2)