| Date | Country | Change |
| 1888.03.05 | Apostolic Vicariate of Idaho lost territory to Diocese of Helena | |
| 1888.03.20 | Apostolic Vicariate of Central Japan 日本中部 was established (from Apostolic Vicariate of Southern Japan 日本南緯) | |
| 1888.05.01 | Diocese of Amida (Syriac Rite) was suppressed (to Diocese of Mardin and Amida) | |
| 1888.05.01 | Diocese of Mardin (Syriac Rite) was renamed as Diocese of Mardin and Amida (gained territory from the suppressed Diocese of Amida) | |
| 1888.05.04 | Apostolic Vicariate of Galla lost territory to Apostolic Vicariate of Aden | |
| 1888.05.04 | Apostolic Prefecture of Aden was promoted as Apostolic Vicariate of Aden (gained territory from Apostolic Vicariate of Galla) | |
| 1888.05.04 | Diocese of Saint Paul was promoted as Metropolitan Archdiocese of Saint Paul (with suffragan see Dakota) | |
| 1888.05.11 | Mission sui juris of Congo Belge was promoted as Apostolic Vicariate of Congo Belge | |
| 1888.06.10 | Apostolic Prefecture of British Honduras was established (from Apostolic Vicariate of Jamaica and without ecclesiastical province) | |
| 1888.08.03 | Diocese of Hobart was promoted as Metropolitan Archdiocese of Hobart | |
| 1888.08.10 | Diocese of Victoria was renamed as Diocese of Victoria–Palmerston | |
| 1888.08.19 | Apostolic Vicariate of Western Siam was promoted as Diocese of Malacca (became suffragan of Pondicherry) | |
| 1888.09.07 | Apostolic Administration of Ticino was promoted as Diocese of Lugano (without ecclesiastical province) | |
| 1888.10.01 | Mission sui juris of I-li 伊犁 was restored (from Apostolic Vicariate of Gansu 甘肅) | |
| 1888.12.25 | Territorial Abbacy of Shën Llezhri i Oroshit was established (from Diocese of Lezhë) |
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