| Date | Country | Change |
| 1820 | Apostolic Vicariate of Great Mogul was renamed as Apostolic Vicariate of Bombay | |
| 1820 | Mission sui juris of Hindustan was promoted as Apostolic Vicariate of Tibet-Hindustan | |
| 1820 | Diocese of Nablus (Maronite Rite) was suppressed | |
| 1820.02.01 | Archdiocese of Québec lost territory to Apostolic Vicariate of Newfoundland | |
| 1820.07.11 | Diocese of Charleston was established (from Metropolitan Archdiocese of Baltimore and became suffragan of Baltimore) | |
| 1820.07.11 | Diocese of Richmond was established (from Metropolitan Archdiocese of Baltimore and became suffragan of Baltimore) | |
| 1820.12.14 | Diocese of Alife was restored (from Diocese of Telese) |
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